Pharmacogenetics is an increasingly important discipline that uses genetic information to tailor the prescription of drug treatments to individuals. In the case of chemotherapy for breast cancer, for example, different patients need and/or respond to different treatments.
Patients whose tumors are HER-2 positive respond to herceptin whereas other patients do not. Patients whose tumors have estrogen receptors will be best served if
A) their estrogen receptors are blocked by using RNAi.B) their estrogen release is activated and/or elevated.
C) the estrogen receptors are blocked by other molecules that can use the same receptors.
D) they are given herceptin as well as estrogen.
E) they are given a complete hysterectomy.
Answer: C
Breast tumor biopsy specimens can be typed for a number of gene expression patterns. Together, these can provide risk analysis for the likely aggressive growth and metastasis of the tumor. How can this most help the physician and patient? A) Some patients want to know as much as possible.
B) This can help them to decide whether and what kind of chemotherapy is warranted.C) This can help them decide whether the tumor should be removed.
D) Some physicians may use the information to decide what to do, but not tell the patient.
E) This can help to aggregate health statistics.
Answer: B
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what is pharmacogenetic testing
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